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Research Overview
Our lab has a background in molecular biology, genetics, neurodegeneration and anatomy.
Currently, we are interested in understanding more about the molecular changes that cause pathogenesis in a the childhood motor neuron disease, spinal muscular atrophy (SMA), with a view to influencing drug discovery. Previously, we have worked on understanding the molecular mechanisms that underlie normal cognitive ageing, health and late-onset Alzheimer's disease.
In our laboratory, we use a wide range of molecular biology techniques to address our research questions, including; analysis of DNA, RNA and protein; gene cloning; in vitro and in vivo analyses of model systems.
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Altered subcellular location of Uba1 in vitro at P7 compared to P3 (Wishart et al., 2014)
Overview of non-neuromuscular systemic pathology in SMA (Hamilton and Gillingwater, 2013).
Abnormal myelination of peripheral nerve in a mouse model of severe SMA (Hunter et al., 2014).
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